Additionally, ZEB1, which is also spatially regulated in cis by a T1D-eQTL (i.e. rs2793108—81 Mb away from the TCF7L2 locus; Supplementary Table S2), encodes a zinc finger transcription factor that functions as a key regulator of the T cell signaling and differentiation in the thymus49. Here, TCF7L2 is linked to type 1 diabetes mellitus.