TLR4 and Immunodeficiency: Here, we identified immune-related genes including Toll pathway, immune deficiency (IMD) pathway prophenoloxidase system (proPO system), pattern recognition proteins (PRPs), blood clotting system, antimicrobial peptides (AMPs), heat shock proteins (HSPs), proteinases and proteinase inhibitors and oxidative stress in shrimp immune network in each stage.