TNF and obesity due to melanocortin 4 receptor deficiency: To further confirm the beneficial effects of IB-hASC therapy on obesity, we examined the gene expression profile of several pro-inflammatory cytokines (Il1ß, Il6, I12 and Tnfα) in both scWAT and vWAT depots of DIO mice treated with saline, W-hASCs or IB-hASCs.