ITGAE and neoplasm: Since it has been well documented that intratumoral XCR1+/CD103+ play a critical role in antigen-presentation by engrafting tumor antigens and migrating to draining lymph nodes in CCR7-dependent homing22, the presence and/or increase of cross-presenting DCs in tumors may be a surrogate marker for T cell priming in tumor-draining lymph nodes.