We found that lymphocytes taken from FM3A tumor-draining lymph nodes of control IgG-treated mice produced a considerable amount of IFNγ when co-cultured with FM3A cells, not by MHC-matched invalid MBT2, suggesting that tumor antigens have been captured by DCs and presented to specific CD8+ T cells in lymph nodes even at baseline in this tumors; however, due to PD-L1-mediated suppression, this may not be sufficient for optimal CD8+ T cell priming to control tumor growth. This evidence concerns the gene CD274 and neoplasm.