Notably, when stably expressed in LNCaP cells (Supplementary Fig. 4d), the ERG-K362A mutant exhibited also reduced ability compared to WT-ERG to promote oncogenic phenotypes, including anchorage-independent growth, colony formation, tumor-sphere formation in prostate-sphere assay, survival in anoikis, and cell migration (Fig. 3h and Supplementary Fig. 4e, f). This evidence concerns the gene ERG and neoplasm.