Contrary to the finding in the current study that Septin4 can promote apoptosis by reducing HIF-1α levels in cardiomyocytes, it has been reported that other proteins in the Septin family like Septin9, can promote tumorigenesis by stabilizing HIF-1α levels in human prostate cancer cells [34, 35]. The gene discussed is HIF1A; the disease is prostate carcinoma.