SPP1 and neoplasm: Of note, the levels of tumor-suppressive genes (TPM4, ANXA1, ANXA6, LIMA1, p53, and DSP) were elevated in β-catenin-overexpressing osteocytes, and CM from β-catenin-overexpressing osteocytes reduced the levels of CXCL1, CXCL5, WISP1, OPN, and M-CSF (Supplementary Fig. 6a, b).