The third mechanism was elevation of Trail and induction of apoptosis, and the fourth was suppression of osteoclastogenesis via inhibition of both TRAP-positive multinucleated osteoclasts and the expression of NFATc1 and cathepsin K. In summary, Lrp5-overexpressing osteocytes markedly reduced tumor progression by regulating tumor-promoting, tumor-suppressing, and apoptosis-inducing genes.24–27. This evidence concerns the gene LRP5 and neoplasm.