RUNX2 and neoplasm: The western blot results showed that in EO771 cells, A5 CM downregulated tumor-promoting genes such as Sclerostin, Lrp5, β-catenin, MMP9, Runx2, TGFβ, and Snail and elevated the level of an apoptosis marker, cleaved caspase 3, more substantially than did Y4 CM (Fig. 1g).