The occurrence of an irAE and serum albumin level were independent predictors after adjusting for age, sex, body mass index, hemoglobin, C-reactive protein, hypertension, diabetes mellitus, dyslipidemia, and cardiovascular history (occurrence of irAE: HR 0.450, 95% CI 0.322–0.630, P < 0.001; serum albumin level: HR 0.438, 95% CI 0.308–0.623, P < 0.001) (Table 5). This evidence concerns the gene CRP and hypertensive disorder.