The functional characterization of these 12 nodes (AKT1, HRAS, PIK3R1, SRC, SOS, GRB2, CDC42, NRAS, SHC1, PPP2CA, BDNF and JNK1) may uncover implications and common patterns on the RASopathies signaling pathways, and their suitability as druggable targets. The gene discussed is GRB2; the disease is RASopathy.