The 11 proteins that do not directly associate with RAS are ANKRD11, MEF2C, SHOX and SRCAP (aforementioned as non-classical RASopathy proteins), KAT6B, CBL, MAP3K8 and A2ML1 (which cause NSL), LZTR1 and RIT1 (responsible for NS), and PPP1CB (which causes NSLSH). The gene discussed is MAP3K8; the disease is RASopathy.