SHOX and RASopathy: 5 (ANKRD11, MEF2C, SRCAP, SHOX and KAT6B) out of the initial 32 proteins were excluded from further analysis based on two factors: no direct association with RAS/MAPK signaling pathway and having an interactome with a protein–protein association overlap with the rest of the RASopathy ́s interactomes below 16%.