CFC syndrome can be caused by mutations in several genes including BRAF [8, 9, 11, 14, 21, 23, 60] with approximately 75% of all cases, MEK1 [8, 23, 61] and MEK2 [9, 14, 23, 62, 63] with another 10 to 15%, and KRAS [23, 60, 64] with fewer than 5%. The gene discussed is BRAF; the disease is cardiofaciocutaneous syndrome.