In particular, they created an interactome network based on interactions between 12 proteins (PTPN11, SOS1, RAF1, BRAF, KRAS, NRAS, HRAS, MAP2K1, MAP2K2, SPRED1, NF1, and RIT1) of the RASopathies and another one based on their 10 first neighbors. This evidence concerns the gene SPRED1 and RASopathy.