Herein, we provide for further studies with a comprehensive up-to-date analysis of 27 RASopathy genes involved in the RAS-MAPK pathway and their interactome, which comprises at least 432 different proteins including 12 nodes, highlighting AKT, HRAS and PIK3R1 as the top three, and involved in several biological processes directly related with the nervous system including but not limited to axonogenesis, peripheral nervous system development and neuron apoptosis. The gene discussed is HRAS; the disease is RASopathy.