Phosphorylation of the RASopathy proteins RAF1 [86], PTPN11 [91, 92], and BRAF [94] is altered in NS and NSML due to mutations in their corresponding genes, whereas RASA1 altered phosphorylation is associated to mutant SHP2 models [92] and not to its own mutation. The gene discussed is PTPN11; the disease is RASopathy.