TNFRSF11B and Townes-Brocks syndrome: After 12 months, by univariate analysis on the whole group of patients, the significant association of TBS with activity disease was not observed and no correlation was found between TBS and disease activity; conversely, TBS showed a negative association with Scl (β – 0.45; p = 0.001), RANKL (β – 0.714, p = 0.0001), and DKK (β – 0.83, p = 0.0001) serum levels and a positive association with OPG (β 0.57; p = 0.0001).