Among individuals destined to develop age-related mild cognitive impairment (MCI) and AD, neuronal loss and neuroinflammation is associated with accumulation of Aβ, so we analyzed the effect of DSS administration on deposition of pathogenic Aβ (Aβ1–40, Aβ1–42) and the potential protective efficacy of NLRP3 depletion (Fig. 4). This evidence concerns the gene NLRP3 and Alzheimer disease.