Considering that the expression of ACE2/Ang 1-7/Mas axis occurs in the skeletal muscle [15], the role of anti-obesity and anti-diabetic of this axis, and the potencial of physical exercise to modulate the RAS (12,13,14), the present study aimed to investigate the effect of APT on muscle morphofunctional markers and ACE2/Ang 1-7/Mas axis in an obesity-linked IR animal model induced by cafeteria diet. The gene discussed is ACE2; the disease is obesity due to melanocortin 4 receptor deficiency.