KIF5C and infection: Given the importance of HIV-1 induced MT stabilization during early infection, along with the fact that post-translationally modified stable MT filaments have a preference for kinesin-1 motors discussed above, it seems likely that HIV-1 has evolved this FEZ1 adaptor-based mechanism to control kinesin-1 activity and facilitate bidirectional movements on stable MTs in order to reach the nucleus.