Then the mRNA expression of prognostic biomarkers between tumor tissues and normal tissues was compared, the results indicated that both the genes including GNRH1 (P < 0.05, Fig. 4B), and LTB4R (P < 0.05, Fig. 4E) were significantly higher expressed in ccRCC samples compared to normal samples. Here, LTB4R is linked to nonpapillary renal cell carcinoma.