The top 25 up-regulated and down-regulated lncRNAs were depicted in Fig. 1A. Among them, dysregulation of CRNDE, PVT1, LINC00152, H19, LEF1-AS1, MEG3 and XIST were proved to involve in the initiation, progression, metastasis and chemoresistance of colon cancer cells, indicating that our transcriptome RNA-sequencing was successful and feasible to explore lncRNAs playing a role in colon cancer tumorigenesis [22–25]. Here, LEF1 is linked to colonic neoplasm.