Previous studies demonstrated that curcumin affected HIFs in tumor cell proliferation and metabolic diseases, e.g., curcumin decreased growth and survival of hepatoma, and breast carcinoma cells through degradation of HIF-1α and HIF-2α (Bahrami et al. 2018; Strofer et al. 2011). This evidence concerns the gene EPAS1 and hepatocellular carcinoma.