The MEK/ERK pathway participates in the regulation of liver injury [27,28] by modulating both cell apoptosis [29] and autophagy [31], and interestingly, researchers notice that ASP regulates the MEK/ERK pathway in osteoarthritis chondrocytes [26], which were validated by our data that DB inactivated the MEK/ERK pathway in the chondrocytes, which were reactivated by co-treating cells with ASP, suggesting that ASP activated the MEK/ERK pathway in DB-treated hepatocytes. This evidence concerns the gene ATG5 and osteoarthritis.