This may explain in part the distinct size effects of induction and rescue of arterial hypertension using our cell-specific eNOS KO/KI mice in the absence and presence of NOS/Arg inhibitors (L-NAME and NorNOHA) and, in particular, the apparent lack of effect of L-NAME in EC eNOS KO mice (which was accompanied by increased mortality in this group only). The gene discussed is NOS2; the disease is Hypertension.