An important finding was that reactivation of eNOS specifically in erythroid cells fully rescued the global eNOS KO (eNOSinv/inv) from hypertension with a significant decrease in BP of 19 to 24 mm Hg (23% decrease in MAP) in the RBC eNOS KI, as compared with their CondKO littermate controls (Table 1 and Table 3). This evidence concerns the gene NOS3 and Hypertension.