Adhesion molecules like L1CAM, which are involved in direct or indirect interactions between tumor cells and their microenvironment, have been identified as potential targets for treatment of cancers [35, 36], especially as L1CAM expression has been linked to augmented protection from apoptosis and increased chemoresistance in various cancer entities including RBs [20, 22, 37, 38]. This evidence concerns the gene L1CAM and cancer.