MAPT and nervous system disorder: However, we do not know whether mechanisms observed in reconstitution assays are biologically relevant in the context of axons [7], especially when considering that none of the above-mentioned factors has genetic links to human neurological disorders on OMIM (Online Mendelian Inheritance in Man), except Tau/MAPT which features primarily with dominant mutations relating to functions less likely to represent its intrinsic MT-regulatory roles [2,17,18].