Eighty-two EC-enriched genes were upregulated in ECs in the tumor core, including collagens (and their modifying enzymes; COL4A1, COL4A2, PXDN), laminins (LAMB1, LAMA4, LAMC1), matricellular proteins (SPARC, HSPG2), adhesion molecules (CD93, MCAM, ITGA5, ITGA1, ITGB1), a vascular permeability marker (PLVAP), and angiogenic molecules (ANGPT2, HSPG2, APLN, KDR). This evidence concerns the gene COL4A1 and neoplasm.