Genes encoding collagens (COL4A1, COL4A2), collagen-modifying enzyme (PXDN), and other components of the basement membrane (LAMB1, HSPG2) also ranked in the top 10 most enriched Co1 EC markers, indicating that extensive matrix remodeling occurs in GBM during tumor angiogenesis. The gene discussed is HSPG2; the disease is neoplasm.