While a similar profile was observed in hAPPWT mice at early and advanced ages, a 2- to 5-fold decrease in Ppara, Acox1, Cpt1a, and Pdk4 mRNA levels was observed (0.46 ± 0.04, 0.58 ± 0.06, 0.50 ± 0.10, 0.91 ± 0.06, respectively) in 11- to 12-month-old hAPPWT mice compared with WT littermates at the same age (Figure 2, C–F), an age at which severe cognitive deficits are detected (32, 35). This evidence concerns the gene PPARA and Cognitive impairment.