Although modifications in brain PPARA, ACOX1, CPT1A, and PDK4 expression observed could be mediated by variations in hAPP expression in AD, a role for hAPP cleavage products including Aβ, tau phosphorylation, brain inflammation, synaptic loss, and amyloid burden reported in AD brains cannot be ruled out (2). Here, PDK4 is linked to Alzheimer disease.