MMP2 and osteosarcoma: Consistent with their role in osteosarcoma, CCN proteins expression foster migration in chondrosarcoma by augmenting expression and enzymatic activity of MMP-13 (Tan et al. 2009a, 2009b; Tzeng et al. 2011), MMP-2 (Hou et al. 2011) or ICAM-1 (Fong et al. 2012).