In addition to frequent bone-metastatic cancer, discussed below, CCN2 is highly expressed in bone invasive oral squamous carcinoma (Shimo et al. 2008), melanoma (Braig et al. 2011) and bone metastasis of hepatocellular carcinoma in both murine models and clinical samples (Hou et al. 2015; Xiang et al. 2011, 2012), where high CCN2 expression positively correlates with rate of bone metastasis (Xiang et al. 2011; Zhang et al. 2019). This evidence concerns the gene CCN2 and melanoma.