Blocking pathways upstream of CCN1 induction, such as IL17 via cyanidin or ferulic acid, or TNFα via SIRT1 or simvastatin, also led to amelioration of RA symptoms (Ganesan and Rasool 2017; Kok et al. 2013; Samarpita et al. 2020). The gene discussed is CCN1; the disease is rheumatoid arthritis.