The pivotal roles of CCN1 and CCN2 in osteosarcoma are corroborated by the decreased expression of miRNAs inhibiting their expression, such as miR-33a, miR-100 and miR-365, and miR-584, respectively (Huang et al. 2014, 2018; Li et al. 2020; Xu et al. 2018); on the other hand, miR-25-3p which indirectly fosters CCN1 and CCN2 expression is up regulated in osteosarcoma (Rao et al. 2020). This evidence concerns the gene CCN2 and osteosarcoma.