CCN1 induces MMP-2, MMP-9, MMP-14 and TIMP-3, mediates prometastatic effects via the IGF-1/IGF1Rβ pathway, and is elevated in MG63 M7 and M10 sublines selected in vivo for a migratory phenotype; in addition, its inhibition decreases lung-metastatic potential of osteosarcoma cell lines in vivo (Chen et al. 2013a; Habel et al. 2015, 2019; Hou et al. 2014). Here, MMP2 is linked to osteosarcoma.