CCN1, CCN2, CCN3 and CCN4 are expressed in enchondromas and low-grade chondrosarcomas, whereas their expression diminishes as disease progresses to higher grades and less differentiated lesions (Hou et al. 2011; Shakunaga et al. 2000; Tan et al. 2009a, 2009b; Yu et al. 2003). Here, CCN3 is linked to chondrosarcoma.