The major representatives of this category are clear cell sarcoma (CCS) of tendon and aponeuroses (mainly EWSR1-ATF1 fusions), malignant gastrointestinal neuroectodermal tumor (mainly EWSR1-CREB1 fusions), angiomatoid fibrous histiocytoma (mainly EWSR1-CREB1 fusions), and clear cell carcinomas of the head and neck (EWSR1-ATF1 fusions) [1]. The gene discussed is EWSR1; the disease is clear cell adenocarcinoma.