In the skeletal muscles of M;G mice, we identified a decreased recruitment of AMPK into the glucose‐sensing v‐ATPase‐Ragulator‐AXIN/LKB1‐AMPK protein complex reported recently,25 leading to decreased phosphorylation of AMPK, which results in less muscle lipid oxidation and subsequent fasting hyperlipidaemia under fasting condition. The gene discussed is AXIN1; the disease is hyperlipidemia.