7,8-DHF has been broadly validated in various BDNF-implicated disease models including a variety of neurological diseases, mental diseases, metabolic diseases, and obesity (Agrawal et al., 2015; Bollen et al., 2012; Chen et al., 2019; Liu et al., 2016b; Pandey et al., 2020; Zhang et al., 2014). Here, BDNF is linked to metabolic disease.