Interestingly, haploinsufficiency in CAMTA1, a member of the calmodulin-binding transcription activators, results in early-onset ataxia in humans [79–81], and nervous system deletion of CAMTA1 in mice causes severe ataxia with Purkinje cell degeneration and cerebellar atrophy [82]. This evidence concerns the gene CAMTA1 and cerebellar ataxia.