Most NAM patients have antibodies against signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a ubiquitous and non-muscle-specific antigen within the endoplasmic reticulum, more often seen in NAM patients associated with cancer. This evidence concerns the gene HMGCR and Bailey-Bloch congenital myopathy.