The earliest mutation version, G614, found in the CV19 spike ‘S’ protein still ‘fits’ to the ACE2/ARB receptor protein but with stronger ability to fuse with host membranes and an at least 3–10 times greater infection capability, causing a mutation for improved survival but not a large structural change while maintaining attachment ability to the ACE2/ARB receptor protein, as confirmed by Choe and Fazan [26]. The gene discussed is ACE2; the disease is infection.