A systems biological assessment of immunity was presented by Arunachalam et al. [77], who noted that “The increase in pro-inflammatory mediators in the plasma, including IL6, TNFRNFS14, EN-RAGE, and OSM, coupled with suppressed innate immune responses in blood monocytes and dendritic cells (DCs) suggest a sepsis-like clinical condition.” In this context, it has been previously suggested that pro-inflammatory cytokines and bacterial products in the plasma may play pathogenic roles in sepsis, and the combination of these factors could be important in determining patient survival. This evidence concerns the gene OSM and Sepsis.