REN and obesity due to melanocortin 4 receptor deficiency: The amount of adipose tissue, rich in angiotensin‐converting enzyme 2 (ACE2) receptors, the association between obesity and with type 2 diabetes which also leads to an increase in ACE2 receptors and an overactivation of the renin‐angiotensin‐aldosterone system in adipose tissue result in difficult systemic hemodynamic control.49