The amount of adipose tissue, rich in angiotensin‐converting enzyme 2 (ACE2) receptors, the association between obesity and with type 2 diabetes which also leads to an increase in ACE2 receptors and an overactivation of the renin‐angiotensin‐aldosterone system in adipose tissue result in difficult systemic hemodynamic control.49 This evidence concerns the gene ACE2 and obesity due to melanocortin 4 receptor deficiency.