NF2 and mesothelioma: Furthermore, co-inactivation of LATS2 and NF2 in mesothelioma cell lines triggers the loss of cell–cell contact inhibition, dysregulation of Hippo and mammalian target of rapamycin (mTOR) signalling, and correlates with higher sensitivity to inhibitors of the PI3K–AKT–mTOR pathway [37].