For example, inhibition of a key component of the glycolytic pathway, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), results in anti-tumour activity in mesothelioma, with death occurring at least in part via the induction of ER stress [97]. This evidence concerns the gene PFKFB3 and mesothelioma.