Another ADC with potent anti-mesothelioma activity, αMSLN-MMAE, is a humanised anti-mesothelin mAb conjugated to the microtubule-disrupting drug monomethyl auristatin A (MMAE) with a lysosomal-protease-cleavable valine–citrulline linker [176]. Here, MSLN is linked to mesothelioma.