F11R and malignant colon neoplasm: These findings were further confirmed in 492 patients in three independent cohorts of stage II colon cancer [GSE40966 [19] (n = 261); GSE14333 [20] (n = 63); TCGA [21] (n = 168)] and, taken together, suggest that JAM-A downregulation has a negative prognostic role in early CRC (Supplementary Fig. S2C–E).