Contrary to the epigenetic regulation of JAM-A expression observed in the RKO CRC cells (Supplementary Fig. S3A, B, D, E), analysis of 50 cases of sporadic CRC did not detect JAM-A promoter methylation (data not shown), suggesting that the reduction in JAM-A expression observed in CRC is not due to epigenetic silencing of the JAM-A promoter. Here, F11R is linked to colorectal carcinoma.