Analyses of JAM-A expression and function in different cancer types including breast [2–4], lung [5] and nasopharyngeal cancers [6], as well as in haematological malignancies [7], have produced conflicting results, suggesting that JAM-A expression and its role in carcinogenesis might be either tissue/organ specific or stage dependent. The gene discussed is F11R; the disease is nasopharyngeal carcinoma.