In order to assess the contribution of JAM-A loss on CRC intracellular signalling, we tested changes in phospho-kinases using a human proteome profiler following conditional JAM-A silencing in Caco-2 (Supplementary Fig. S3C and Fig. 4A) and DLD-1 cells (Supplementary Fig. 3F and Supplementary Fig. S5A). The gene discussed is F11R; the disease is colorectal carcinoma.