In order to test whether JAM-A dysregulation also influenced the metastatic potential of CRC cells, we performed tail vein injections of DLD-1 cells expressing the JAM-A or control shRNA constructs and monitored their ability to colonise the lungs over a period of 12 weeks (Fig. 3F and Supplementary Fig. S4B). The gene discussed is F11R; the disease is colorectal carcinoma.