Although we did not explore any causal relation between β-catenin activation, MIR21 overexpression and JAM-A downregulation, it is noteworthy that, similarly to JAM-A loss [52], MIR21 is also able to promote pSer552 phosphorylation of β-catenin and its nuclear translocation in APC mutant colon cancer cells [54]. This evidence concerns the gene APC and colonic neoplasm.