MIR21 and colorectal carcinoma: While exploring whether the reduction in JAM-A expression observed in CRC might be due to MiRNA-mediated silencing, we identified a putative binding site for MIR21, one of the most significantly upregulated MiRNAs in CRC [38], in the JAM-A 3′-untraslated region (UTR) (Fig. 5A).