ALYREF and epidermolysis bullosa: Furthermore, there were major differences in the IgG responses detected upon the vaccination of mice with the purified antigens, and the human IgG responses to Sle1, Aly or LytM detected as a consequence of natural exposure to these antigens due to S. aureus colonization of chronic wounds in the case of EB patients, or due to carriage or incidental contacts in the case of healthy volunteers.