The increased serum concentrations of resistin and a positive correlation between the levels of resistin and the activity of inflammatory processes were observed in numerous autoimmune and inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, systemic sclerosis, Sjogren’s syndrome and inflammatory bowel diseases3,25,26. This evidence concerns the gene RETN and rheumatoid arthritis.