Furthermore, miRNA was also compared between A375SM-EV and A375-EV through miRNA array (Table S1), since we have found that A375SM-TEC showed a higher level of IL-6 than did A375-TEC, as shown in Fig. 1A. Furthermore, miR-1246 was picked up because its level was higher in the CM from tumor cells than in that from normal cells and also in A375SM-EV than in A375-EV (Fig. 3A). The gene discussed is IL6; the disease is neoplasm.