We selected a cohort of patients with invasive breast carcinoma treated between 2005 and 2010 at Tianjin Medical University Cancer Hospital, China, consisting of 161 grade 3 no special type (IBC-NST) HR-negative carcinomas (HER2-positive or TNBC) with positive LNs (Fig. 1). The gene discussed is ERBB2; the disease is carcinoma.