Inhibition of BRD4 by (+)-JQ1, inhibit histone methyltransferase G9a or enhance the histone deacetylase SIRT1 to inhibit BRD4, downregulate GPx4, SLC7A11, SLC3A2 gene expression, regulate ferritinophagy, and induce ferrroptosis in cancer cells [71]. The gene discussed is BRD4; the disease is cancer.