Numerous studies have shown that RAG1 and RAG2 were found to be expressed at both protein and mRNA levels in many cancer cell lines, including colon cancer, lung cancer, cervical cancer, liver cancer, prostate cancer, nasopharyngeal cancer, gastric cancer, breast cancer, papillary thyroid cancer, pancreatic cancer, ovarian cancer, soft tissue sarcoma, and lymphoma [14, 16, 18, 29, 31, 34, 37, 38, 58, 66]. The gene discussed is RAG2; the disease is colonic neoplasm.