The other biological functions of tumor-derived Igs are as follows: (1) tumor-derived Igs regulate immunity [75]; (2) tumor-derived Igs facilitate drug resistance in tumor cells [77]; (3) tumor-derived Igs might be involved in pancreas cancer-associated diabetes [18]; (4) tumor-derived Igs affect tumor-associated thrombosis [88]; (5) tumor-derived Igs mediate cancer stem cell (CSC) potential [77]. Here, CUBN is linked to pancreatic neoplasm.