At present, the transcription factors of the B-cell-derived IgG gene include octamer-related protein 1, 2 (Oct-1, 2), nuclear factor kappa B (NF-κB), B-cell Oct-binding factor-1, etc., while there is no Oct-2 among the transcription factors of tumor-derived IgG. Here, NFKB1 is linked to neoplasm.