CEBPA and acute myeloid leukemia: Moreover, an N-terminal truncation, but not an AML-associated C-terminal mutation, was found to have a suppressive (dominant negative) effect on wt C/EBPα transcriptional activity in 293 T cells, whereas the opposite effect was observed on the expression of G-CSFR (a target of C/EBPα) in mouse myeloid cells [19].