By adding cADPR and 8-Br-cADPR to co-culture tumor cells, we found that cADPR inhibited the expression of KEAP1, but promoted the expression of NRF2 in CD38 KO and MU tumor cells, while 8-Br-cADPR was on the contrary (Fig. 6D). The gene discussed is CD38; the disease is neoplasm.