Analysis differences of pathways between A549 CD38 WT and CD38 KO tumor cells by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified cell cycle, cell proliferation, stress-activated MAPK signaling, cell metabolic, and other signaling pathways were changed (Fig. 6A, B). The gene discussed is CD38; the disease is neoplasm.