To demonstrate whether VPA treatment has a beneficial effect on muscle strength and performances, we employed three different functional tests (grip strength, gait analysis, and treadmill exhaustion tests) on Sgcb-/-/Rag2γc-/- dystrophic murine model, resembling Limb Girdle muscular dystrophy type 2E. The gene discussed is SGCB; the disease is autosomal recessive limb-girdle muscular dystrophy type 2E.