However, earlier studies have associate hypomethylation of cg05429895 with increased expression of TLR4. For example, Yu et al. report hypomethylation of this same site to induce increased expression of TLR4 and NF-κB, leading to the development of intracranial aneurysms [65]. This evidence concerns the gene TLR4 and Dilatation of the cerebral artery.