We identified 345 genetic variants jointly associated with neuroticism and CVD risk factors as well as CAD; 30 for CAD, 96 for BMI, 46 for DBP, 60 for SBP, 22 for WHR, and 29 for HDL, as well as between 9–36 for each of PP, T2D, TG, TC, LDL, CRP, and one for CIGPRDAY. The gene discussed is CRP; the disease is type 2 diabetes mellitus.