There are some defects in the protein structure or genetic disorder causing asthenozoospermia [40], including defects in the flagella and cilia [47], defects in the sperm channels located in the sperm tail membrane like Cation channels of sperm (CaTSper channels) [48]; defects in ATP production by Glycolysis and oxidative phosphorylation (OXPHOS) in the flagellum’s central piece, head, and mitochondria [49]; and reduction in the cyclic AMP that is essential for regulating sperm motility [50]. This evidence concerns the gene CATSPER1 and hereditary disease.