HIF1A and diabetes mellitus: Additionally, dacosahexaenoic acid is a type of omega-3 polyunsaturated fatty acid, which is reported to not only be effective for diabetes, but also for cancer with its anti-proliferative, anti-angiogenesis, anti-invasion, anti-metastatic and pro-apoptotic properties, via negatively regulating HIF1-α levels, leading to downregulation of glycolytic enzymes in breast cancer cells [189].