Furthermore, metformin is also reported to promote AMPK signaling mediated apoptosis in breast cancer cells and white adipose tissue endothelial cells [187], which have been shown to play a cooperative role in breast cancer angiogenesis and metastasis, hence modulating both the tumor and its microenvironment, specifically in TNBC and HER2 positive breast cancer cells. Here, ERBB2 is linked to breast cancer.