Nine genes (EGR1, SFRP1, TGFBR1, RFLNB, MYL9, CAVIN1, THY1, STAT3, and TRBC2) (Fig. 2C) showed obvious correlations with Tim-1 knockdown, which also indicated the correlation between the abnormally expressed Tim-1 and TGFBR1 in glioma. This evidence concerns the gene STAT3 and central nervous system cancer.