TGFBR1 and glioblastoma: In previous study, Tim-1 initially functions as a crucial costimulatory molecule on T cell surface, and we are the first study to analyze the important role of Tim-1 in regulating the proliferation, migration, and invasion of glioblastoma cells via the miR-133a/TGFBR1 axis and the Wnt- β catenin pathway.