Nine genes (EGR1, SFRP1, TGFBR1, RFLNB, MYL9, CAVIN1, THY1, STAT3, and TRBC2) (Fig. 2C) showed obvious correlations with Tim-1 knockdown, which also indicated the correlation between the abnormally expressed Tim-1 and TGFBR1 in glioma. The gene discussed is SFRP1; the disease is central nervous system cancer.