Under light microscopy, compared with primary IgA nephropathy, IgA-dominant postinfectious glomerulonephritis was more likely to form crescents (p = 0.05), and endocapillary hypercellularity were more severe (p < 0.001), accompanied by significant neutrophil and monocyte capillary infiltration, and obvious blockage of the lumen, indicating that the disease may have more serious effect and destruction on renal structure. The gene discussed is CD79A; the disease is IgA glomerulonephritis.