STAT3 and glioblastoma: 2017). Protein tyrosine phosphatase receptor type M (PTPRM) belongs to the protein tyrosine phosphatase (PTP) family, members of which have been reported to have a potential tumour inhibition effect (Tonks 2006). Meanwhile, it has been reported that the overexpression of the PTP family of molecules (DUSP26 or PTPRT) in E98 GBM cells decreases the incidence of tumours (Bourgonje et al. 2016). PTPRM is a member of the PTP family that targets the STAT3 pathway, and its overexpression has been shown to directly reduce the phosphorylation of STAT3 Y705 (Im et al. 2020).