CYP2E1 and fibrosis: 2015). Concurrently, CYP2E1 is an important drug metabolizing enzyme, and its high activity promotes the production of ROS and leads to the destruction of cell membrane, which seriously affects the function of DNA and protein (Rukkumani et al. 2004; Hau et al. 2009). Once the antioxidant activity of liver is inactivated by ROS and free radicals, the liver will be attacked (Wong et al. 2001), and then the liver will be damaged to produce diseases such as hepatitis, fibrosis and even cirrhosis (Noh et al. 2011).