Helicobacter pyloriis a small gram-negative bacillus that has been linked to the development of gastric cancer by infecting gastric epithelial cells and producing oxidative stress that modifies the intra-gastric environment.34 Two of its virulence factors, the cytotoxin-associated gene A (CagA) and the vacuolating cytotoxin A (VacA), are polymorphic and affect several host cellular pathways.35 Even though there is some data to support a potential association between H. Pylori and CRC, its association remains controversial. The gene discussed is S100A8; the disease is gastric cancer.